July 31, 2025

Clinical and Demographic Characteristics Associated with Diabetes Remission in Six Integrated Health Care Systems: A Retrospective Cohort Study

Key Points

Type 2 diabetes remission occurred in 2.9% of the cohort over three years, demonstrating a low rate of success.
Key factors linked to remission included not using glucose-lowering medications, lower baseline HbA1c, and shorter diabetes duration.
A retrospective cohort methodology analyzed over 556,000 adults using health record data from six health care systems.
Understanding these characteristics can inform targeted strategies for identifying patients most likely to achieve diabetes remission.

Abstract

Objective: To assess the real-world frequency and characteristics associated with type 2 diabetes remission in a large and diverse cohort of U.S. adults. Research Design and Methods: Retrospective cohort using 2014–2023 electronic health record data from six major U.S. healthcare delivery systems. The cohort included 556,758 adults (≥18 years) with type 2 diabetes who had ≥1 HbA1c measurement in 2 years before study entry and evidence of glucose-lowering medication use. Pregnant women or adults who underwent bariatric surgery before or during the study were excluded. Type 2 diabetes remission was defined as HbA1c

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