Supplementary Figure S1 from Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors

Key Points

• Hereditary diffuse gastric cancer analysis identifies signet ring cell precursors with an indolent phenotype.
• Enriched pathways relating to ECM remodeling were observed between signet ring cells and epithelial precursors.
• Leading edge analysis post-GSEA indicates crucial biological differences between the two cell types.
• Findings enhance understanding of cancer progression and may inform future therapeutic strategies.