The rising global incidence of type 2 diabetes has increased the demand for safe, effective, patient-compliant alternatives to traditional antidiabetic medications. This study presents the development and evaluation of Ayurvedic antidiabetic gummies as a next-generation herbal supplementation. A comprehensive polyherbal gummy was developed using standardized extracts of Gymnema sylvestre, Momordica charantia, Trigonella foenum-graecum, Syzygium cumini, Curcuma longa, and Ocimum sanctum with careful selection of gelling agents and natural sweeteners for palatable, effective tasting gummies. The gummie was then phytochemically profiled utilizing HPTLC and LC-MS for accurate analysis of components. In vitro antidiabetic assays (α-amylase and α-glucosidase inhibition) were performed as well as DPPH scavenging for antioxidant activity in conjunction with the in viv antidiabetic potential in streptozotocin-induced diabetic rats over 21 days with continued safety studies, organ histopathology and analysis of preliminary human trial data for changes in fasting blood glucose, and HbA1c. The formulated gummies showed excellent physicochemical stability, palatability, and compliance. Phytochemical analysis confirmed the retention of key bioactives post-processing. The in vitro assays demonstrated significant enzyme inhibition and antioxidant activity. In vivo, the gummies reduced fasting glucose levels, improved insulin sensitivity, and showed no hepatic or renal toxicity. Human participants showed a reduction in fasting glucose and HbA1c over 60 days with no reported adverse effects.
Singh et al. (Wed,) studied this question.