Supplemental Figure S2 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5

Key Points

• Collagen XVII promotes tumor growth in pancreatic ductal adenocarcinoma by regulating PIK3R5, enhancing cancer cell proliferation.
• Co-culture experiments showed increased expression of COL17A1 in pancreatic ductal adenocarcinoma cells due to CAF interaction.
• Assessment of tumor growth dynamics highlighted the significance of the interaction between PDAC cells and cancer-associated fibroblasts.
• This study suggests that targeting these molecular pathways could offer new therapeutic strategies against pancreatic ductal adenocarcinoma.