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September 5, 2025Open Access

Śānto Agniḥ Mriyate: Understanding Sepsis and Multi-Organ Failure through Dhatvagni and Hormonal Regulation

Key Points

The proposed model connects dhatvagni and hormonal regulation, affecting metabolism in sepsis and multi-organ failure.
Research highlights a potential overlap between traditional Ayurvedic concepts and modern hormonal functions with metabolism as the core focus.
Endocrine hormones, such as insulin and cortisol, play crucial roles in managing energy dynamics between anabolic and catabolic processes.
Understanding this link could improve clinical approaches to managing sepsis and multi-organ failure, bridging traditional and modern medical insights.

Abstract

Ayurvedic perspective: Concept of agni 1) jatharagni 2) bhutagni 3) dhatvagni. Modern perspective: Hormonal regulation of metabolism in tissues (insulin, glucagon, thyroid, cortisol, GH, sex hormones). Rationale: Tissue-level metabolism in Ayurveda (dhatvagni) has conceptual overlap with hormone-controlled tissue energetics in modern physiology. Research gap: Lack of systematic mapping between dhatvagni and endocrine regulation. Objective: To propose a conceptual model linking dhatvagni with modern endocrine functions. Metabolism is the sum of all chemical reactions in the body, encompassing both anabolic (building) and catabolic (breaking down) processes. Hormones, secreted by various endocrine glands, serve as the body’s regulatory signals, orchestrating when and how energy is stored or utilised. Their precise balance ensures stable blood glucose, efficient energy use, and adaptation to stress, growth, and reproduction.

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