Children with diabetes and at least one non-autoimmune feature should be considered for monogenic diabetes testing

Abstract Aims Monogenic diabetes testing in children currently targets Maturity Onset Diabetes in the Young (MODY) or recognised genetic syndromes. We aim to determine whether genetic testing for monogenic diabetes should be performed for all children with diabetes and at least one non-autoimmune extra-pancreatic feature (syndromic diabetes). Methods We recruited 183 children with diabetes and at least one non-autoimmune extra-pancreatic feature (50% (n=91) with self-reported consanguinity). We measured islet-autoantibodies and type 1 diabetes genetic risk score (T1DGRS) and used targeted next generation sequencing to analyse all known causes of monogenic diabetes. Results 33% (61/183) of children had confirmed monogenic diabetes. Of these, 84% (51/61) had recessive aetiologies with variants in WFS1 (46%), SLC19A2 (12%) and SLC29A3 (12%) being most common. Monogenic cases compared to non-monogenic had similar age of diagnosis (7.4 vs 6, p=0.1) and BMI z-score (-0.08 vs -0.41, p=0.3) but had higher parental consanguinity (62% vs 19%, p=0.01) and features in multiple organ systems (53% vs 28%, p=0.01). Only 59% reported well recognised features of their associated genetic syndrome. Children with low T1DGRS (50th centile of T1D population) and negative/untested antibodies were more likely to have monogenic cause compared to positive antibodies or negative/untested antibodies and a high T1DGRS (≥ 50th centile) (48% vs 3% vs 7%, p0.0001). Interpretation Children with diabetes and at least one non-autoimmune extra-pancreatic feature should be considered for monogenic diabetes testing. Measurement of islet-autoantibodies and T1DGRS help prioritise genetic testing.