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September 10, 2025

Synthesis and Characterization of 5-substituted-1,3,4-oxadiazole-2-thione (4)

Key Points

The synthesized 5-substituted-1,3,4-oxadiazole-2-thione derivatives show significant biological activities.
Key biological properties include antioxidant, antibacterial, antifungal, antitumor, and analgesic effects.
Spectral analysis confirmed the successful characterization of the synthesized compounds.
The study emphasizes the importance of 1,3,4-oxadiazole in pharmaceutical applications and drug development.

Abstract

1,3,4-oxadiazoles are a class of heterocyclic five-membered compounds with two nitrogen and one oxygen that are highly important in pharmaceutical science. This nucleus has four isomeric forms: 1,2,4-oxadiazole; 1,3,4-oxadiazole; 1,2,5-oxadiazole; and 1,2,3-oxadiazole. This nucleus has been shown to have many biological activities, including antioxidant, antibacterial, antifungal, antitumor, antidepressant, anticancer, and analgesic properties. In the present investigation 5-substituted-1,3,4-oxadiazole-2-thione (4) derivatives were synthesised in four steps and characterized using spectral analysis.

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