What type of study is this?

This is a Literature Review study.

September 10, 2025

Radiation-dependent Nucleic Acid Sensing, and Its Possible Impact on Radiotherapy

Key Points

Activation of DNA and RNA-sensing mechanisms during radiotherapy influences tumor cell behavior and immune response.
cGAS and AIM2 pathways, along with RNA-sensing proteins, play significant roles in mediating inflammation and DNA damage.
Innate immune signaling triggered by radiation may alter the tumor microenvironment, affecting treatment outcomes.
Recent insights emphasize the relationship between sterilized inflammation and tumor response during radiotherapy.

Abstract

DNA damage and chromosomal instability can promote sterile inflammatory responses in cells, similar to those induced by pathogen infection. Primary contributors to this phenomenon are cGAS-dependent and AIM2-dependent DNA-sensing mechanisms, as well as RIG-I-dependent, MDA5-dependent, and ZBP1-dependent RNA-sensing mechanisms. Work over the last decade has established that some or all of these pathways may also be activated by radiotherapy, potentially modulating the behavior of irradiated tumours. With an emphasis on tumor cells, we review here how innate immune signalling may become activated during radiotherapy, and how it may impact the behavior of irradiated cells, as well as how this might pattern the tumor microenvironment.

AI से पूछें

Bookmark

Cite This Study

Pickering et al. (Tue,) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec33e https://doi.org/https://doi.org/10.1097/ppo.0000000000000775

AI से पूछें

Bookmark