Background and Aims: The widespread of Mpox, a zoonotic disease, beyond its endemic regions and declaration of Mpox as a public health emergency by WHO, has raised a global concern. This study aims to compare and analyze the response of various regions across the globe to recent Mpox outbreaks, identify key lessons learned, and propose future strategies to improve public health preparedness. Methods: We conducted a narrative review using PubMed, Google Scholar, and Scopus to identify peer-reviewed articles and official reports published between 2022 and 2024. Countries were selected based on geographic diversity, incidence rates, and data availability. Key comparison parameters included timing of interventions, vaccine rollout, public awareness, diagnostic capacity, and resource allocation. A regionally stratified, thematic analysis was performed to assess the effectiveness of national responses to the Mpox outbreak. Results: The analysis indicates that there is a high degree of dispersion in the measured outcomes of responses. Countries with a pre-implemented vaccination plan like the UK and USA presented with much lower infection rate than the countries that took reactive measures. Awareness activities in high-risk areas, together with quarantine measures, caused a tremendous reduction of transmission. Nevertheless, there were visible chinks in the knowledge-sharing and funding in global health and this led to higher incidence of infection among the communities with limited access to resources like Nigeria and DRC. Conclusion: This narrative review demonstrates the importance of customized global coordination and flexibility of public health responses when dealing with emerging infectious diseases. The different regional responses underscore the essentiality of nuanced interventions, early detection, and effective public health messaging. While some territories have been highly proactive and shown excellent management of the situation, others are struggling with resource constraints and a less well-informed population. Future efforts to provide disaster relief should place a greater emphasis on global collaboration, health system strengthening, and training public health professionals. The world can draw lessons from what has worked well or not so well with the current Mpox response to help prepare and mitigate future public health emergency.
Anjum et al. (Wed,) studied this question.