Type 2 diabetes mellitus (T2DM) stands as one of the most prevalent and complex metabolic diseases globally because of insulin resistance and beta-cell dysfunction alongside sustained hyperglycemia. Continuous calorie restriction serves as the standard dietary management approach, yet patients struggle to stick to it throughout the long term. Intermittent fasting (IF) has emerged as a new dietary approach which involves scheduled eating periods combined with fasting times without requiring constant caloric restriction. Time-restricted feeding and alternate-day fasting and the 5:2 diets represent three popular fasting methods. Research indicates that IF produces substantial benefits for blood sugar management and overall metabolic health in T2DM patients. The evidence demonstrates that IF leads to better insulin sensitivity together with decreased fasting glucose levels and glycated hemoglobin values and improved post-meal glucose management. The fasting regimen helps patients lose weight while reducing their visceral fat and enhancing their lipid profiles and decreasing systemic inflammation. The observed effects stem from hormonal changes together with improved mitochondrial function and enhanced autophagy and reduced oxidative stress levels. The implementation of IF requires special caution for patients who take insulin or sulfonylureas because it may lead to hypoglycemia. The implementation of IF requires evaluation of nutritional needs together with patient compliance and psychological elements. The following groups should not receive IF treatment: pregnant women and older adults with frailty as well as individuals who have eating disorders. Under proper clinical supervision and individualization IF provides an effective tool for diabetes care programs. Standard practice implementation of this approach demands proper patient selection and educational programs and continuous monitoring. Future research should concentrate on studying long-term outcomes and developing biomarker-based personalized approaches and integrating IF with current pharmacological and lifestyle treatments.
Alsefri et al. (Wed,) studied this question.