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September 10, 2025Open Access

Factors Associated with Exertional Desaturation in Patients with Chronic Obstructive Pulmonary Disease

Key Points

Exertional desaturation was experienced by 10.3% of participants during the 6MWT.
Old age, ex-smoker status, low forced expiratory volume, and high COPD assessment test scores showed significant associations with desaturation.
Observational analysis utilized data from the KOrea COPD Subgroup Study, including 1789 participants.
Results highlight the need for early identification of at-risk patients to manage COPD more effectively.

Abstract

The six minute walk test (6MWT) has a prognostic role in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to determine the factors associated with desaturation during the 6MWT in patients with COPD. This study utilized data from the prospective KOrea COPD Subgroup Study (KOCOSS) cohort. The results of the 6MWT performed at enrollment were analyzed in this study. A total of 1789 participants performed the 6MWT. Among them, 185 (10.3%) experienced desaturation during 6MWT. Old age, ex-smoker, low forced expiratory volume in one second (%), and high COPD assessment test score were significantly associated with exertional desaturation.

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