What type of study is this?

This is a Case Report study (also classified as: Immunohistochemical analysis, MRI).

September 10, 2025

Angioleiomyoma of the hard palate: Report of a case and clinical, imaging, immunohistochemical analysis

Key Points

Histopathological analysis diagnosed the lesion as angioleiomyoma, signifying a rare tumor.
Imaging via MRI revealed heterogeneous hypo-intensity and hyper-intensity patterns indicative of the tumor.
A 14 × 8 × 6 mm mass was surgically excised from the right hard palate with positive findings for specific markers.
This case presents unique insights as the first reported angioleiomyoma occurrence in Korea’s hard palate.

Abstract

Angioleiomyoma, also known as vascular myoma or vascular leiomyoma, is a rare benign tumor originating from smooth muscle cells of the tunica media of blood vessels, characterized by numerous blood vessels and spindle-shaped smooth muscle cells. A 40-year-old Korean female was referred with a 14 × 8 × 6 mm pedunculated, elastic mass on the right hard palate. She reported the lesion had been present for one year without pain or noticeable growth. MRI showed a uniform signal pattern with heterogeneous hypo-intensity on T1-weighted and hyper-intensity on T2-weighted images. The tumor was excised under local anesthesia. Histopathology showed cytoplasmic positivity for SMA, Desmin, and Caldesmon, and negativity for pan-cytokeratin, S-100, CD31, CD34, and HMB45. Based on these findings, the lesion was diagnosed as angioleiomyoma. This represents the first reported case of angioleiomyoma occurring in the hard palate in Korea.

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