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September 10, 2025

Quantitative Analysis of Amlodipine Tablets in the Libyan Market Using Ultraviolet Spectrophotometry

Key Points

The method achieves a high correlation coefficient (r2 = 0.9992) in analyzing amlodipine tablets.
Detection limits for amlodipine were set at 1.62 µg/mL, ensuring precise measurement for quality control.
This ultraviolet spectrophotometric method demonstrated linearity for AMD in the 5-30 µg/mL concentration range.
The validation based on ICH standards confirms the method's robustness for monitoring medications in Libya.

Abstract

A simple, precise, and accurate UV-spectrophotometric method was developed for the quantitative analysis of amlodipine (AMD) in various tablet brands available in Libya. This method was used to determine AMD at its maximum absorbance (λmax) of 238 nm in methanol. The method demonstrated linearity in the concentration range of 5-30 µg/mL for AMD drugs, with a notably high correlation coefficient (r2 = 0.9992). The detection limit and quantification limit were determined to be 1.62 and 4.88 µg/mL, respectively. The suitability of the developed method for quantitative determination of drug was proved by ICH validation. The method was effectively employed to analyze amlodipine tablets available in the Libyan market.

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