Lung Cancer in Non-Smokers. Prospective descriptive study of a cohort of 68 patients.

Introduction: Lung cancer in never smokers (LCINS) is considered as a separate entity given its epidemiological specificities. Materials and methods: This is a prospective multi-centric epidemiological study of 68 patients treated and followed for LCINS (less than 100 cigarettes during all lifetime). Its main objective was to describe clinical features, molecular somatic profile, the risk-factors exposure, and survey in never smokers. Results: Between juin2017 and februry2019 a cohort of 60 (88%) women and 08 (12%) men was collected, with a median age of 59 years.Two-third were exposed to passive smoking (mainly women and in domestic setting). Domestic use of biofuels is present in 43% of cases and the exposure to cooking oil is almost present in women, with median duration of 10 years. The frequent common symptom is cough in 43% of cases. Thoracic CT found opacity in 94% cases ; peripheral topography is present in 63% of cases. Adenocarcinoma is found in 75% of cases, and the EGFR mutation is present in 34% of cases. The majority of patients are classified as stage IV (74%), systemic treatment is used in 98% of cases. After follow-up time of 10 months, the therapeutic results are marked by objective response in 44% of cases; radiological stability is maintained in 41% of cases. Overall survival is 15,4 months with extremes of 03 and 24 months. Conclusion: LCINS is an interesting entity for the study of nontobacco-related cancer risk factors.