What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Pitfalls in unedited 2-HG MRS detection with optimized TE at 3T

Key Points

False-positive detections of 2-HG can mislead clinicians, especially when metabolites overlap.
Spectral overlap with metabolites like GABA and acetone was identified as a significant source of error.
Patients with IDH-mutated glioma are at risk of inaccurate 2-HG estimates due to these pitfalls.
Insights from this research stress the importance of careful interpretation of MRS data in clinical settings.

Abstract

Motivation: Detection of D-2-hydroxyglutarate (2-HG) using in-vivo magnetic resonance spectroscopy (MRS) is a highly promising potential biomarker for diagnosis and treatment monitoring in IDH-mutated glioma. Goal(s): This study investigates how 2-HG estimates from unedited MRS (at optimized TE) depend on different modeling strategies. Approach: We analyzed MRS data from patients with IDH-mutated glioma with different modeling strategies, focusing on the effect of spectral overlap on 2-HG quantification. Results: Spectral overlap with metabolites like GABA and acetone can lead to false-positive 2-HG detections in normal-appearing contralateral brain tissue. Clinicians need to be mindful of these pitfalls when interpreting 2-HG estimates. Impact: This study highlights that false-positive 2-HG MRS detection can occur in normal-appearing brain tissue and identifies signal overlap (with GABA, acetone, etc.) as the primary reason. 2-HG estimates should be interpreted carefully in clinical context, including dietary preferences or interventions.

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Cite This Study

Alçiçek et al. (Tue,) studied this question.

synapsesocial.com/papers/68d45b0b31b076d99fa5d21f https://doi.org/https://doi.org/10.58530/2025/0885

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