Stereoselective synthesis of P-stereogenic nucleotide prodrugs and oligonucleotides

Key Points

• Recent advances in stereoselective synthesis enhance the development of new nucleotide prodrugs and oligonucleotides.
• The review discusses both chemical strategies and enzymatic approaches, indicating a diversified methodology in synthesis.
• By focusing on P-stereogenic compounds, this synthesis promises improved efficacy in therapeutic applications.
• These advancements could lead to significant breakthroughs in pharmaceutical development, highlighting the potential for innovative treatments.