A BSTRACT Background: Cirrhosis of the liver disrupts lipid metabolism, leading to alterations in serum lipid profiles. The Child-Pugh and Model for End-Stage Liver Disease (MELD) scores are widely used to evaluate severity of liver diseases and to predict outcomes. This study explores the relationship between serum lipid profiles and the severity of liver cirrhosis as determined by validated scoring systems. Methods: A cross-sectional observational study was conducted at a single tertiary care center in Maharashtra, India, over the period of 2 years, involving a total of 59 adults (either gender) with liver cirrhosis. Data on demographic characteristics, lipid profiles (total cholesterol, triglycerides, HDL, LDL, and VLDL), and liver disease severity (Child-Pugh and MELD scores) were collected and analyzed using SPSS software. Results: A total of 59 cirrhotic patients, predominantly male (72.9%) with a mean age of 50.5 ± 10.5 years, were studied. Alcoholic liver disease (33.9%) was the leading cause of cirrhosis. A significant inverse correlation was observed between serum lipid levels and disease severity, with reductions in total cholesterol, HDL, LDL, and triglycerides in patients with higher Child-Pugh and MELD scores. The study also demonstrates a strong inverse correlation between serum lipid profiles and the severity of liver cirrhosis. A statistical test ANOVA showed significant lipid level differences, P < 0.001. Conclusion: Lipid profiles, particularly HDL and LDL levels, could serve as valuable biomarkers for assessing liver function and disease progression. These results can be further validated in a larger cohort study.
Doshi et al. (Mon,) studied this question.
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