September 30, 2025Open Access

Antibiotic usage in surgical prophylaxis: a prospective observational study in the surgical wards of a tertiary care hospital

GVG. VijayaraniVinayaka Missions Medical College and Hospitals BTBizimana Rukundo T.Vinayaka Missions Medical College and Hospitals KSK SudhaGovernment of Tamil Nadu

Key Points

Surgical prophylaxis was administered appropriately in about 80.7% of cases before incision, indicating positive adherence to timing.
Cefotaxime was the most frequently used antibiotic, especially in obstetrics at 100%, showing a preference for specific antibiotics.
Prolonged prophylactic use occurred in several departments, indicating a deviation from standard guidelines and practices.
Discontinuation of antibiotics within 24 hours after surgery was seen in 77.8% of general surgery cases, suggesting varying adherence.

Abstract

Background: Surgical site infections (SSIs) are a leading cause of postoperative complications, particularly in resource-limited settings. Surgical antibiotic prophylaxis (SAP) is an effective measure for preventing SSIs when administered with appropriate antibiotic selection, timing, and duration. This study aimed to evaluate the SAP practices in elective surgeries and assess adherence to national and international guidelines. Methods: A prospective observational study was conducted over six months at a tertiary care teaching hospital, including 293 patients undergoing elective surgical procedures in the departments of general surgery, orthopaedics, ENT, gynaecology, and obstetrics. Data on the choice of prophylactic antibiotics, timing relative to surgical incision, and duration of postoperative use were collected and compared with guidelines from the Indian council of medical research (ICMR), American society of health-system pharmacists (ASHP), and the world health organization (WHO). Results: General surgery accounted for 51.9% of procedures, followed by orthopaedics (25%) and ENT (13.5%), with gynaecology and obstetrics together at 9.6%. Cefotaxime was the most frequently used antibiotic, particularly in obstetrics (100%) and general surgery (70.4%), whereas gynaecology predominantly used a cefotaxime-metronidazole combination (66.7%). SAP was administered within the recommended 60-minute window before incision in 80.7% of cases, with the highest adherence in obstetrics (100%). Discontinuation within 24 hours occurred in 77.8% of general surgery and 92.3% of orthopaedic cases, whereas extended use was common in obstetrics, ENT and gynaecology. Conclusions: Although SAP timing was generally appropriate, the overuse of third-generation cephalosporin, the absence of cefazolin, and prolonged prophylaxis in some departments highlight the need for department-specific guideline adherence.

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