Abstract Background Cytomegalovirus (CMV) tends to reactivate in immunocompromised individuals. Patients with hematological malignancies are at high risk of CMV infection due to treatment-related immunosuppression, and sepsis may further promote latent CMV reactivation via inflammatory disorders. However, research on active CMV infection in patients with both conditions remains limited; Methods: A single-center retrospective cohort study included 119 patients with hematological malignancies complicated by sepsis (Ningbo Medical Center Lihuili Hospital, June 2022–June 2025). Patients were divided into active CMV infection group (plasma CMV DNAemia ≥ 500 copies/mL, 41 cases) and non-active group (P P P P = 0.021) with optimal predictive value (AUC = 0.746); hemoglobin and platelet count also had good predictive value; Conclusions: Patients with hematological malignancies complicated by sepsis have high active CMV infection incidence (mostly early hospitalization), associated with poor prognosis. Decreased white blood cell count is a useful early screening indicator, requiring early clinical monitoring and intervention.
Chen et al. (Wed,) studied this question.