A 15-minute 860um whole-brain MR-Fingerprinting and DTI epilepsy protocol demonstrated on 51 medial temporal lobe epilepsy patients.

In this work, we combined a 5-minute whole-brain 0.86mm-iso 3D-MR fingerprinting (MRF) with a 10-minute whole-brain 0.86mm-iso diffusion MRI protocol, to achieve high-fidelity whole-brain T1/T2/PD and diffusivity maps at sub-millimeter isotropic resolution. This protocol was applied to medial temporal lobe epilepsy (MTLE) patients to enable accurate detection of the hippocampal sclerosis. A multi-parametric analysis was implemented with whole-brain subcortical segmentation. A multi-component 2D-relaxometry spectra was estimated with non-negative joint sparsity for robust suspicious lesion detection.