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A virtual manner of determining apparent stiffness values from diffusion images, so called ‘vMRE’, was evaluated in this study which included both healthy subjects and patients with Non-Alcoholic Fatty Liver Disease (NAFLD). No association was observed between true MR-Elastography (MRE) and vMRE. However, the difference between MRE and vMRE was more strongly correlated with T2*. Iron deposition is not uncommon in patients with NAFLD, and for that reason, a spin echo-MRE sequence was used, instead of the gradient-based sequence that has been used previously. Iron deposition in liver shortens T2*, which can also affect diffusion images and the vMRE.
Eriksson et al. (Wed,) studied this question.