An application of diffusion tensor image analysis along perivascular space (DTI-ALPS) in grading gliomas and predicting IDH1 mutation status

Glioma could impair the glymphatic function with reduced CSF outflow. We aimed to use DTI-ALPS method to investigate the pathological change of glymphatic function in gliomas and evaluate its value in grading gliomas and predicting IDH1 mutation status. The lower-grade gliomas (LrGGs) showed higher ALPS Index than glioblastomas (GBMs). IDH1 wild-type group showed decreased ALPS Index compared with the IDH1 mutant group in LrGGs. But there was no difference between the IDH1 subtypes in GBMs. The ALPS Index showed good efficiency in grading gliomas and predicting IDH1 mutation status, it may be a potential imaging biomarker for diagnosing gliomas.