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Voxel misalignment due to unavoidable respiratory motion and bulk motion introduce large errors in DW-MRI quantitative parameter fitting. Apparent diffusion coefficient (ADC) is an effective tool for characterization of malignant tumors. In this study we evaluate the use of a motion correction method for DW-MRI imaging based on 3D slice level motion tracking using a rigid slice to volume registration and Kalman filtering. We show improvement in robustness of parameter estimation and reduction of blurring in b-value images for assessment of pediatric hepatoblastoma lesions.
Vasylechko et al. (Wed,) studied this question.