Bias Correction for Improved Quantification of Hyperpolarized 1-13CPyruvate Cerebral Perfusion

Bias correction of hyperpolarized 1-13Cpyruvate brain MRI allows for improved quantification of cerebral perfusion. In the healthy volunteers studied, bias corrected pyruvate and ASL rCBF exhibited higher correlation than uncorrected pyruvate and ASL rCBF. We hypothesize that N4ITK bias correction can be used to remove low frequency inhomogeneities from hyperpolarized MRI before single-metabolite analyses.