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Abstract Arsenic contamination in environmental waters poses global health and environmental risks. This study addresses the urgent need for rapid, selective, and sensitive detection of inorganic arsenic (iAs III ) in environmental samples. Leveraging the unique properties of gold nanoparticles (AuNPs) and the selective binding affinity of homocysteine (Hcy), we developed a novel colorimetric sensor for iAs III detection. Our investigation elucidates the mechanism by which Hcy modifies AuNPs, enabling the selective detection of iAs III ions through chelation between amine and carboxyl groups, primarily with the predominant species H 2 AsO 3 − at pH 12.0. Our sensor achieves high selectivity (>10‐fold) for iAs III amid various interfering ions commonly found in environmental samples. Furthermore, we demonstrate exceptional sensitivity in detecting iAs III , with a low limit of detection (LOD) of 67 nM, aligning with regulatory standards for arsenic concentration in drinking water. The selectivity and sensitivity of our sensor were validated through experiments with various metal ions and real water samples. In conclusion, our study presents a comprehensive understanding of the mechanism, selectivity, and sensitivity of Hcy‐modified AuNPs in detecting iAs III , offering a versatile nanosensor platform with significant implications for environmental monitoring and public health.
Tseng et al. (Mon,) studied this question.