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July 8, 2024Pharmaceutics11 citationsOpen Access

Quality-by-Design-Driven Nanostructured Lipid Scaffold of Apixaban: Optimization, Characterization, and Pharmacokinetic Evaluation

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KPKiran PatilNGNayan A. GujarathiCSCharu Sharma

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Abstract

Apixaban, an anticoagulant, is limited in its efficacy due to poor solubility, low bioavailability, and extensive metabolism. This study investigates the application of nanostructured lipid carriers (NLCs) to enhance the bioavailability of Apixaban. NLCs were prepared using the high-pressure homogenization method. The influence of independent variables, viz., the amount of Tween 80, HPH pressure, and the number of HPH cycles, were studied using a 2

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Patil et al. (2024) studied this question.

synapsesocial.com/papers/68e60f70b6db6435875a2dc4https://doi.org/10.3390/pharmaceutics16070910
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