Effects of Bryophyllum Pinnatum Leaf Extract on the Prostrate Specific Antigen and Liver Enzymes in Albino Rats

This study was carried out to determine the effects of Bryophyllum pinnatum leaf extract on Prostrate specific antigen, Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT), levels of albino rats.Thirty-five albino rats were randomly divided into five groups with seven rats in each group (n=7); Control (C) received normal feed only.Group 1 was administered with Bryophyllum pinnatum leaf extract 100 mg/kg, Group 2: Bryophyllum pinnatum extract 150 mg/kg, and Group 3 received Bryophyllum pinnatum leaf extract 200 mg/kg.Group 4: received Bryophyllum pinnatum leaf extract 250 mg/kg.This lasted for 28 days.Group 3 and 4 showed significantly decreased PSA (1.08±0.29ng/ml;1.18±0.32ng/ml)AST (14.19±0.64iu/l,14.05±0.71iu/l)and ALT (10.12±0.73iu/l,10.98± 0.98iu/l) when compared with the control (PSA 2.08±0.29ng/ml,AST 16.41±0.93,ALT 13.77±0.51)respectively at p < 0.05.Bryophyllum pinnatum leaf extract has a hepatoprotective and prostrate protective effect.