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Background: Respiratory disorders lead to mental stress and reduce the quality of life. Hence, there is a need to intervene with traditional healthcare systems. One such healthcare system being practised in the Southern Peninsula is Siddha. Siddhars used herbs, inorganic substances, and animal products to formulate a medicine for maintaining the balance of trihumors (Vali, Azhal and Aiyam). Sarva Sangaara Uppu Parpam is one of the formulations made using herbs indicated for respiratory disorders. Aim: The current study was carried out to analyse the antihistamine and antimicrobial of Siddha medicine Sarva Sangaara Uppu Parpam (SSUP). Methods: Antihistaminic activity was done by isolated chick ileum method and anti-microbial activity for respiratory pathogens like Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumonia, Candida albicans, Escherichia coli, Pseudomonas aeruginosa was determined by disc diffusion method. Result: The results show a statistically significant difference in the response curve of histamine with mean and standard deviation values of 6.5 and 2.258 at p < 0.001. Thus, the drug was effective against pathogens such as K. pneumonia, P. aeruginosa and fungal pathogen C. albicans with a maximum inhibitory zone of 12 mm. This medicine has antihistaminic and antimicrobial activity against K. pneumoniae, P. aeruginosa and C. albicans. The results of this study should have extended analysis through further preclinical analysis and clinical trials are necessary to establish the safety and efficacy of SSUP.
Govindarasu et al. (Sun,) studied this question.