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June 26, 2024American Journal of Respiratory and Critical Care Medicine55 citations

The Effect of PEEP on Pulmonary Vascular Resistance Depends on Lung Recruitability in ARDS Patients

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SBSimone Cappio BorlinoJHJulien HagryCLChristopher Lai

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Abstract

A U-shaped relationship should exist between lung volume and pulmonary vascular resistance (PVR), with minimal PVR at FRC. Thus, positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS) should increase PVR if it induces significant lung distension compared with recruitment. However, this has never been proved in patients.

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Borlino et al. (2024) studied this question.

synapsesocial.com/papers/68e6327cb6db6435875c4119https://doi.org/10.1164/rccm.202402-0383oc
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