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The simple, precise and accurate UV spectroscopic method has been developed for simultaneous estimation of amlodipine besylate and atorvastatin calcium. The developed simultaneous equation method is reproducible and economical. The wavelengths selected for measuring the absorbance of both drugs were 365 and 246 nm, respectively. In a concentration range of 2 to 10 μg/mL, amlodipine besylate and atorvastatin calcium exhibited linearity at their respective λmax of 365 and 246 nm as well as at the isoabsorptive point at 238 nm. Recovery studies showed recovery of >99.78% for amlodipine besylate and >99.36% for atorvastatin calcium, indicating method accuracy. The developed method is suggested for routine analysis because it is quick, easy, accurate, as well as sensitive and specific. The validation studies were carried out in accordance with the International Council of Harmonization (ICH) recommendations.
Mali et al. (Tue,) studied this question.