Long-term outcomes following paclitaxel-coated balloons versus thin-strut drug eluting stents for treatment of in-stent restenosis in Chronic Coronary Syndrome (CCS Dragon-Registry)

Background:The long-term outcomes for patients with in-stent restenosis (ISR) presenting with chronic coronary syndrome (CCS) are not well studied. Aims:We aimed to investigate the outcomes for patients with drug-eluting stents (DES)-ISR and CCS undergoing percutaneous coronary intervention (PCI) with drug-coated balloons (DCB) or thin strut-DES. Methods: A total of 846 consecutive patients from the Dragon-Registry with CCS and DES-ISR who underwent PCI with thin (strut thickness <100 μm) strut-DES (381 45%) or paclitaxel-DCB (465 55%) for DES-ISR were enrolled between February 2008 and October 2021.The median follow-up was 1006 (IQR 426-1770) days.The primary outcome was target lesion revascularization (TLR).Secondary outcomes were target vessel revascularization (TVR) and device-oriented composite endpoint (DOCE: cardiac death, TLR, or target vessel myocardial infarction TV-MI).