Risk factors for anastomotic leakage in colonic procedures within an ERAS‐protocol. A retrospective cohort study from the Swedish part of the international ERAS‐database

Abstract Background Research on anastomotic leakage (AL) in colonic procedures within an Enhanced Recovery After Surgery (ERAS) protocol has not yet been conducted. The aim of this study was to identify risk factors for AL after colonic surgery. Methods The study included all consecutively recorded patients operated with colonic resection surgery in the Swedish part of the international ERAS ® Interactive Audit System (EIAS) between September 2009 and June 2022. The cohort was analyzed and evaluated regarding risk factors for AL. Results Altogether 10,632 patients were included, 10,219 were without AL and 413 (3.9%) were with AL. After adjusted analysis, male sex (4.6% AL), OR: 1.49; 95% CI (1.16–1.90), obesity (4.8% AL), OR: 1.62; 95% CI (1.18–2.24), previous surgery (4.4% AL), OR: 1.45; 95% CI (1.14–1.86), open surgery (4.4% AL), OR: 1.36; 95% CI (1.02–1.83), anastomosis between small bowel and rectum (13.1% AL), OR: 3.97; 95% CI (2.23–7.10), stapled anastomosis (5.3% AL), OR: 2.46; 95% CI (1.79–3.38), inhalation anesthesia (4.2% AL), OR: 1.80; 95% CI (1.26–2.57), and conversion to open surgery (5.5% AL), OR 1.49; 95% CI (1.02–2.19) were significant risk factors for AL. Although pre and intraoperative compliance to the ERAS‐protocol was similar, excess of fluids day 0 was an independent predictor for AL. Conclusion Male sex, obesity, previous surgery, open surgery, stapled anastomotic technique, anastomosis between small bowel and rectum, inhalation anesthesia, conversion to open surgery, and among ERAS interventions, excess of fluids day 0, were significant risk factors for AL.