Analysis of the Mediating Effect of Nontraditional Lipid Parameters in the Relationship Between Body Mass Index and Blood Pressure in Chinese Adolescents

Objective: To analyze the mediating role of non-traditional lipid parameters in the relationship between body mass index (BMI) and blood pressure in children and adolescents, and to provide a reference basis for the development of hypertension prevention and treatment strategies in children and adolescents. Design and method: A stratified whole-group random sampling method was used to select 1796 children and adolescents aged 12 to 18 years from middle and high schools in Ningxia for physical examination and laboratory testing, and a mediating effect model was used to analyze the mediating effect of nontraditional lipids on the relationship between BMI and blood pressure. Results: Among the nontraditional lipid parameters, all of them were significantly associated with blood pressure except Non-HDL-C (all P<0.001); three of them, Remnant Cholesterol (RC), TG/HDL-C and RC/HDL-C, had significantly higher effects on blood pressure than the others (all P<0.001). HDL-C, RC and RC/HDL-C partially mediated the relationship between BMI and blood pressure, with the three mediating effects accounting for 5.2%, 6.9%, and 7.5% of the relationship between BMI and diastolic blood pressure and 4.4%, 3.0%, and 3.8% of the relationship between BMI and systolic blood pressure, respectively (all P<0.001). Conclusions: Nontraditional lipid parameters are associated with blood pressure and partially mediate the relationship between BMI and blood pressure, and more attention should be paid to the role of monitoring nontraditional lipid parameters in the management of blood pressure in children and adolescents.