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Nanotechnology is very important in targeting drug delivery, which shows much more interest of researchers. Many orally administered drugs are ineffective as desired because certain side effects such as systemic toxicities, slow onset of action, first pass effect, poor bioavailability etc. Topical route in combination with nanotechnology on the other hands offers bundle of benefits. It can provide predictive and controlled drug release, by pass first pass effect, improves drug bioavailability, pain free route, steady state blood concentration etc. There are many factors, such as the type of nonionic surfactant used, method of preparation, the temperature of hydration, etc. which affect the noisome based nano-carrier formation. But application of niosomes in the gel form make it more convenient to use by enhancing its bioavailability and reducing the side effects. Although these benefits make topical drug delivery system a better route for drug administration but certain barriers such as permeation through skin always challenging. In this review article, we have made an attempt to incorporate all the basic details of noisome gels based on methods of preparation, characterization, way to overcome the barriers and their applications along with novel advancements taken place in the field of nanotechnology.
Faheem et al. (Thu,) studied this question.
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