Orodispersible Tablets: A Novel Approach to Combat Dysphagia

Drug administration via the oral route highly favoured due to its simplicity in taking medication, avoidance of discomfort, adaptability, and most importantly, its ability to promote patient compliance.Scientists have been keen on devising innovative oral delivery of drugs to increase patient acceptance.Over the past decade, there has been a continuous surge in the demand for Orodispersible tablets also known as mouth dissolving tablets (MDTs), leading to the rapid expansion of this sector within the pharmaceutical industry.Mouth dissolving drug delivery systems (MDDDS) have gained significant prominence in the market due to their ability to address past administration challenges.MDTs are specifically formulated to disintegrate and dissolve in saliva, allowing for easy swallowing with no need of water.Hence, MDTs are very much attractive to the patients with dysphagia, individuals who are bedridden, those with psychological conditions, the pediatric and geriatric patients.This stands as a significant advantage over traditional dosage forms.These tablets can be manufactured through several conventional tablets manufacturing techniques, spray drying, moulding, sublimation, also freeze drying.In recent times, various patented technologies have emerged, offering improved performance, heightened patient adherence, and enhanced overall quality.Furthermore, there has been a substantial rise in new chemical entities discovery for novel delivery technology.This review encompasses a comprehensive discussion of formulation aspects, developed technologies, excipients, evaluation tests, and marketed formulations of MDTs, as well as an examination of evaluation parameters encompassing before and after-compression criteria, alongside considerations for the packaging of MDTs.