489 Lymphocyte to monocyte ratio as a prognostic factor in ovarian cancer

Introduction/Background The presence of a lower preoperative level of lymphocytes is usually associated with poor outcomes in advanced stage ovarian cancer, revealing a poor response of the immune system to tumoral cells. The aim of the current paper is to investigate the correlation between preoperative lymphocyte to monocyte ratio and the perioperative outcomes of patients with epithelial ovarian cancer. Methodology Between 2014–2020 there were 107 cases of patients diagnosed with advanced stage epithelial ovarian cancer who were submitted to debulking surgery with curative intent. Results Mean preoperative level of lymphocyte to monocyte ratio (LMR) was 3,12 (range 0,7 -6,7) and was significantly correlated with more advanced stages of the disease (p=0,023), with the presence of lymph node metastases (p=0,038), with higher levels of CA125 (p=0,04) and with a poorer disease free and respectively overall survival (p=0,01 and respectively pConclusion LMR seems to be a promising marker in order to identify cases with a poorer biology of the tumor in which a more aggressive systemic therapy could be necessary in order to improve the long term outcomes. Disclosures None.