873 Clinico-pathologic features and prognostic variables of epithelial ovarian cancer patients at elshatby university hospital

Introduction/Background Ovarian cancer is one of the top five causes of cancer-related mortality in women. The most prevalent is the epithelial OC (EOC). Immunohistochemical and genetic research showed that ovarian cancer is a heterogeneous collection of tumours with varying risk factors and prognosis. Methodology A retrospective analysis of primary EOC patients who received primary cytoreductive surgery at Elshatby University Hospital (Alexandria, Egypt) between 2019 and 2021 was conducted. 123 women's clinical and demographic data were analyzed. Patients with insufficient data were excluded. The Kaplan-Meier survival curve estimates overall (OS) and progression-free survival (PFS). Cox regression determined prognostic factors' significant associations. Results The median age was 56 years, and most patients were postmenopausal (66.7%) and multiparous (74.0%). The most prevalent complaint was abdominal pain (56.9%). Tumours were 87% ovarian and 13% tubal in origin. 54.5% and 45.5% underwent upfront and interval cytoreduction, respectively, and 95.9% of patients received chemotherapy. LN was positive in 43.1%, and recurrence occurred in 49.6%. FIGO stages I, II, III, and IV were found in 11.4%, 8.9%, 70.7%, and 8.9% of patients, respectively. High-grade serous was the most common subtype (74.8%). Clear cell, low-grade serous, high and low-grade endometrioid, and mucinous infiltrative and expansile types represented 1.6%, 8.9%. 8.1%, 0.8%, 4.1%, and 1.6%, respectively. FIGO stage and LN positivity are significantly associated with PFS and OS. The 3-year PFS and OS were 100% and 91.7%, 53.0% and 87.5%, 38.3% and 76.1%, 0.0%, and 17.0% for stages I, II, III, and IV, respectively. 3-year PFS and OS were 64.6% and 79.2% for negative LN, versus 16.0% and 66.1% for those with positive LN. Conclusion In EOC, FIGO stage and LN positivity have a significant impact on OS and PFS. Histological type and origin did not significantly affect OS and PFS within a follow-up period of 2–5 years. Disclosures The authors declare no conflict of interest. This research received no external funding.