1339 Endometrial cancer in pre-menopausal women

Introduction/Background Endometrial cancer is a disease that occurs mainl in postmenopausal women, with the majority of cases diagnosed at the sixth or seventh decades of life. However, there is an increasing number of premenopausal women diagnosed with endometrial cancer each year. Methodology Retrospective study of 28 premenopausal women with endometrial cancer, treated at the Carcinological Radiotherapy department, FarhatHached Hospital, Tunisia, between 1995 and 2020. Results The median age was 48 16–51. A family history of endometrial cancer was found in 2 patients. At the time of diagnosis, 12 patients were childless (42.9%) and 4 had primary infertility (14.3%). Diabetes and high blood pressure were found in 21,4% and 17,9% of cases, respectively. Twelve patients were overweight (42,9%). The median patient-delay was 7.5 months 2–24. Main circumstances of discovery were metrorrhagia and pelvis pain in 71.4% and 17.8% of cases, respectively. The majority of patients (89.3%) underwent total hysterectomy with bilateral adnexectomy. Pelvic lymph node dissection was performed in 13 cases (52%). Histological analysis showed endometrioid adenocarcinoma, sarcoma and Müllerian tumor in 71,4%, 14,3% and 14,3% of patients, respectively. According to the FIGO-2018, stage distribution was as follows : 9 cases (32,1%) in stage I, 9 in stage II, 5 (17,9%) in stage III and 5 cases in stage IV. Pelvic radiotherapy was performed in 27 cases (96.4%), with curative intent in 23 cases, with a dose of 50–66.6Gy. Twelve patients (42,9%) recieved chemotherapy and only one patient had vaginal brachytherapy. After a median follow-up of 32 months 4–252, 19 patients were in complete remission (67,9%) and 9 patients died following metastatic relapse (44,5%) and progression (55,5%). Conclusion The number of endometrial cancers in premenopausal group is in a rising trend. However, patients usually presented with an early disease and generally, it is associated with a good prognosis and better survival. Disclosures The authors declare that they do not have a conflict of interest.