Positive effects of Andrographis paniculata extract on growth performance, haematology, serum biochemistry, organosomatic indices and resistance against Aeromonas hydrophila in hybrid catfish ( Clarias macrocephalus × Clarias gariepinus )

This research was conducted to determine the effects of Andrographis paniculate extract on hybrid catfish. The fish were fed 0, 0.2, 0.4 and 0.6 g/kg extract to supplement their diets for 90 days. The highest weigh gain, average daily growth, specific growth rate, feed efficiency and protein efficiency ratio, as well as the lowest feed conversion rate, were found in the group fed 0.6 g/kg. RBC were at their highest in all treatment groups, while the highest levels of total WBC and haematocrit percentage were observed in the group fed 0.6 g/kg. ALT and triglyceride were at their lowest levels in all treatment groups, while the highest amounts of glucose were found in all treatment groups. The highest levels of high-density lipoprotein and the lowest cholesterol were observed in fish fed 0.6 g/kg. Lysozyme activity was initially observed at a significant difference on days 60–90, the highest activity was found in the group fed 0.6 g/kg. After bacterial challenge test, lysozyme activity and WBC were significantly increased in all treatment groups, the lowest cumulative mortality was found in the group fed 0.6 g/kg. These results suggest that 0.6 g/kg of the extract has positive effects on hybrid catfish.