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PATIENTS AND METHODS: in this pilot study using classical culture methods and analysis of 16S rDNA libraries sequenced on the Illumina MiSeq platform, we characterized the mucosa-associated microbiota of four diverticula in resected colon specimens of patients. RESULTS: in all the samples the abundance of Enterobacteria and the shift towards the predominance of Bacteroides in the ratio of Prevotella-to-Bacteroides (P/B) was detected. In three samples, Firmicutes prevailed over Bacteroidetes. Also, in three samples the balance in the microbial landscape was strongly shifted towards one genus: Bacteroidetes, Parvimonas, Akkermansia, or Bifidobacterium. CONCLUSION: microbiota inside inflamed diverticula revealed the specific shifts in the intestinal microbiome that may contribute to the progression of inflammation in the diverticulum up to its inflammatory destruction.
Shakirov et al. (Tue,) studied this question.