October 17, 2025

Supplementary Figure 2 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Key Points

The study illustrates the difference in mutation detection between tumor tissue and plasma DNA.
Discordant mutations were observed in patients stratified by biopsy sites, showcasing complexity in genomic profiling.
The analysis emphasizes the need for accurate genotyping methods to guide cancer treatment decisions.
Findings from the NCI-MATCH trial provide critical insights into mutation landscapes across different tumor samples.

Abstract

Supplementary Figure 2. Summary of genomic landscape in patients enrolled based on outside laboratory testing who had discordant mutations. Patients are stratified according to the site of tissue biopsy (primary or metastatic site). Triangles are used to depict the presence of mutation in tissue (lower triangle) and/or plasma (upper triangle).

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Cite This Study

Gouda et al. (Wed,) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb7d https://doi.org/https://doi.org/10.1158/1078-0432.30363483

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