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October 23, 2025Open Access

Impurity profiling of multicomponent cough syrup containing Brompheniramine, Dextromethorphan and Phenylephrine by RP-HPLC with PDA detector

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Authors

PPPriyanka Raju PataskarGBGayatri BarabdeVBVijay Arjun Bagul

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Overview

This analysis demonstrates robust impurity profiling of phenylephrine in cough syrup, indicating validation of the RP-HPLC method for quality control.

Key Points

  • Impurity profiling reveals critical details about component quality in cough syrup, enhancing safety and efficacy.
  • Validation shows the RP-HPLC method is reliable with high repeatability for analyzing phenylephrine and impurities.
  • Analytical techniques include gradient mode with UV detection, ensuring effective separation and identification of impurities.
  • Robustness of the method suggests it is suitable for routine quality control in pharmaceutical settings.

Cite This Study

Pataskar et al. (2025) studied this question.

synapsesocial.com/papers/68f984011881b68f3b7ae306https://doi.org/10.21203/rs.3.rs-7427571/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  3. 3Stability-Indicating RP-HPLC Determination of Acetylsalicylic Acid, Dextromethorphan Hydrobromide, Phenylephrine Bitartrate, and Chlorpheniramine Maleate in an Effervescent Tablet Formulation2026
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  5. 5Development and Validation of a RP-HPLC Method for Simultaneous Quantification of Paracetamol and Phenylephrine Hydrochloride2024 · 7 citations