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December 1, 2021New England Journal of Medicine871 citationsOpen Access

21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer

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KKKevin KalinskyWBWilliam E. BarlowJGJulie R. Gralow

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Abstract

Among premenopausal women with one to three positive lymph nodes and a recurrence score of 25 or lower, those who received chemoendocrine therapy had longer invasive disease-free survival and distant relapse-free survival than those who received endocrine-only therapy, whereas postmenopausal women with similar characteristics did not benefit from adjuvant chemotherapy. (Funded by the National Cancer Institute and others; RxPONDER ClinicalTrials.gov number, NCT01272037.).

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Kalinsky et al. (2021) studied this question.

synapsesocial.com/papers/691221fea24073d8361a67e5https://doi.org/10.1056/nejmoa2108873
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