Abstract Purpose: To analyze the prevalence of malignant lip, oral cavity and pharynx neoplasms in Brazil from 2017 to 2023 in order to identify the epidemiological profile of patients, compare prevalence rates, and understand possible socio-environmental factors associated with higher prevalence and mortality. Methods: A cross-sectional, descriptive, retrospective study utilizing public and secondary data from the Department of Information and Informatics of the Unified Health System platform. The variables analyzed related to patients hospitalized and mortality rate for lip, oral cavity, and pharynx malignant neoplasms were: Brazilian region, sex and race, from 2017 to 2023. Results: Between 2017 and 2023, 177, 415 hospitalizations due to malignant neoplasms of the lip, oral cavity and pharynx were recorded in Brazil, with 5, 212 in the North, 38, 531 in the Northeast, 81, 586 in the Southeast, 38, 986 in the South, and 13, 100 in the Midwest. These figures correspond to 0. 03%, 0. 07%, 0. 09%, 0. 13%, and 0. 08% of the average population in each region during the period, respectively. However, the mortality rate showed a different distribution, being highest in the North (15. 06), followed by the Southeast (12. 94), Midwest (12. 54), Northeast (11. 35), and South (10. 21). Hospitalizations were also more prevalent amongst men, accounting for 130, 518 cases, approximately 74% of the total, compared to 46, 897 cases amongst women, approximately 26%. When analyzing by race, the proportion between men and women was consistent with the average for white, black, mixed-race, and Asian populations. However, amongst the Indigenous population, the distribution was more balanced, with 67% of cases in men and 33% in women. Conclusion: Although the prevalence of the disease is lower in the North, the mortality rate is approximately 25% higher than the national average. Furthermore, the disease is significantly more prevalent amongst men than women. These disparities can be explained by socio-environmental factors, such as the cultural practice of chewing tobacco in the North, the higher prevalence of smoking and alcohol consumption amongst men and excessive sun exposure, especially in rural occupations predominantly held by men, which is associated with lip cancer. The more balanced distribution of prevalence amongst the Indigenous population may be linked to cultural and ritualistic characteristics tobacco, also practiced by women, but could indicate gaps in case reporting as well. Citation Format: Luiza Nodari Candanedo, Ana Lúcia Soares Rosson, Gabriela Gerevini Dal Alba, Jéssica Meazza Bohnenberger, Júlia Larsen Dorcinio, Mariana Schlindwein Afonso, Rafaela Coelho Pires, Yasmin Marques Loureiro. Epidemiological Profile of the Hospitalizations and Mortality Rate for Malignant Lip, Oral Cavity and Pharynx Neoplasm in Brazil from 2017 to 2023 abstract. In: Proceedings of the 13th Annual Symposium on Global Cancer Research; 2025 Sep 16. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34 (12Suppl): Abstract nr 30.
Rosson et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: