Enhanced antibacterial and antioxidant capabilities using indole-modified 1-phenyl-1 H -pyrazolo3,4- b pyridine-5-carbonitrile derivatives, molecular docking evaluation and in silico ADMET prediction

Key Points

• Compounds improved antibacterial effects against dominant bacterial strains, suggesting therapeutic value.
• The synthesized derivatives showed strong antioxidant potential in the DPPH assay, with effective activity levels observed.
• Molecular docking and in silico ADMET prediction provided insights into the compounds' behaviors and interactions in biological systems.
• This study highlights the promising pharmacological applications of pyrazolo derivatives in developing new antimicrobial agents.