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December 8, 2025Open Access

Ischemic Stroke in Hypereosinophilic Syndrome: A Clinicopathologic Study of Two Cases

Key Points

Two cases presented showed ischemic stroke in patients with hypereosinophilic syndrome, raising awareness of CNS complications.
Pathologic examination revealed specific CNS infarcts linked to hypereosinophilic syndrome, emphasizing its potential neurologic impact.
Assessments based on post‐mortem neuropathologic examinations highlight the rarity of ischemic strokes in hypereosinophilic syndrome.
Further research needed, as understanding CNS involvement may improve clinical outcomes in hypereosinophilic syndrome.

Abstract

ABSTRACT Ischemic stroke is a rare complication of hypereosinophilic syndrome (HES). Manifestations of stroke in HES have been described in the radiologic literature; however the pathologic characterization of central nervous system (CNS) involvement in HES is limited. In this small case series, we present two post‐mortem neuropathologic examinations of patients exhibiting CNS infarcts associated with HES and review the relevant literature.

Ischemic Stroke in Hypereosinophilic Syndrome: A Clinicopathologic Study of Two Cases

Key Points

Abstract

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