Elevated Lp(a) is associated with an increased risk of abdominal aortic aneurysm, confirmed by multivariable Mendelian randomization in over 1,000 AAA cases.
Is elevated Lipoprotein(a) associated with an increased risk of abdominal aortic aneurysm?
Elevated Lipoprotein(a) is causally associated with an increased risk of abdominal aortic aneurysm, identifying it as a potential modifiable risk factor and therapeutic target.
Absolute Event Rate: 0% vs 0%
Lp(a) is a genetically determined lipoprotein targeted by emerging therapies. In a UK Biobank analysis (1,026 abdominal aortic aneurysm AAA cases, 469,989 controls), elevated Lp(a) was associated with increased risk of AAA, including at clinically relevant thresholds while controlling for traditional risk factors, including ApoB. Multivariable Mendelian randomization confirmed a causal relationship between lipoprotein(a) Lp(a) and AAA independent of apolipoprotein B. These findings support Lp(a) as a modifiable risk factor and potential therapeutic target for AAA, a condition with limited medical treatment options. AAA should be considered as an outcome in future clinical trials of Lp(a)-lowering therapies.
Sharma et al. (Tue,) reported a other. Elevated Lp(a) is associated with an increased risk of abdominal aortic aneurysm, confirmed by multivariable Mendelian randomization in over 1,000 AAA cases.