Fibroadenoma of the Breast (FAM) is a benign fibroepithelial breast tumor influenced by estrogen and progesterone through their binding to Estrogen Receptor-a (ER-a) and Progesterone Receptor (PR). These receptors are thought to contribute to mammary tissue proliferation; however, the role of stromal ER-a and PR in determining tumor size remains unclear. This study aimed to analyze the correlation between stromal ER-a and PR expression and FAM tumor size using archived specimens from RSI UNISMA. An analytic observational study with a cross-sectional design was conducted on 24 archived FAM tissue samples, with tumor size obtained from medical records. ER-a and PR expression in stromal tissue were evaluated using immunohistochemistry and quantified with ImageJ software. Data were analyzed using Spearman correlation with p0.05), although ER-a and PR contributed 23% and 11% respectively to tumor size variation. In conclusion, stromal ER-a and PR expression were not significantly associated with FAM tumor size, likely due to their dominant expression in ductal epithelial rather than stromal tissue.
Isdiawan et al. (Fri,) studied this question.