What question did this study set out to answer?

This study investigates how different wavelengths of low-level laser therapy affect bone regeneration during suture expansion in rats.

January 18, 2026

Investigation of the Effects of Low‐Level Laser Therapy in Different Wavelengths on Inter‐Premaxillary Expansion in Rats Using Micro‐Computed Tomography and Histological Methods

Key Points

This study investigates how different wavelengths of low-level laser therapy affect bone regeneration during suture expansion in rats.
Divided sixty rats into five groups for control and four laser treatment conditions.
Applied a 30-g force expansion appliance after drilling the upper incisors.
Administered laser therapy at 48-hour intervals for 14 days.
Measured bone regeneration using micro-computed tomography and immunohistochemistry.
Significantly higher alkaline phosphatase levels in the 940 nm group on Day 7.
Both alkaline phosphatase and BMP-2 levels increased significantly in the 940 nm group on Day 14.
Lower trabecular separation observed in the 940 nm group compared to control on Day 14.

Abstract

ABSTRACT Objectives This study aims to investigate the effects of low‐level laser therapies (LLLTs) with four different wavelengths (532, 650, 810 and 940 nm) on new bone regeneration during inter‐premaxillary suture expansion in rats. Materials and Methods Sixty rats were divided into five groups ( n = 12): control (Group A) and four laser groups (Group B: 940 nm, Group C: 810 nm, Group D: 650 nm and Group E: 532 nm). Each group was further divided into two subgroups ( n = 6) based on the sacrifice day: Day 7 and Day 14. The upper incisors of the rats were drilled, and a 30‐g force expansion appliance was inserted. The study lasted 14 days, with 7 days of expansion and 7 days of retention. LLLT was administered at 48‐h intervals in groups other than the control group. Bone regeneration in the suture was assessed using micro‐computed tomography and immunohistochemistry. Trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp) were measured by using micro‐computed tomography. Alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP‐2) and tartrate‐resistant acid phosphatase (TRAP) immunoreactivity intensities were calculated in the immunohistochemically stained upper jaw sections. Results In Group B (940 nm), ALP was significantly higher on the 7th day ( p < 0.001); ALP and BMP‐2 were significantly higher ( p = 0.002; p = 0.013, respectively), and Tb.Sp was significantly lower on the 14th day ( p = 0.034) compared with the control group. Conclusions The results show that 940 nm low‐level laser therapy accelerates bone regeneration more effectively in the expanded inter‐premaxillary suture.

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Cite This Study

Isgandarov et al. (Fri,) studied this question.

synapsesocial.com/papers/696c77d4eb60fb80d1396100 https://doi.org/https://doi.org/10.1111/ocr.70072

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