What question did this study set out to answer?

This research aims to investigate how the BDNF rs6265 polymorphism affects both motor and non-motor symptoms in individuals with Parkinson's disease.

January 22, 2026Journal of Movement Disorders0 citationsOpen Access

Longitudinal implications of BDNF rs6265 polymorphism on motor and non-motor features of Parkinson’s disease in Korean population

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SYSang-Won YooCatholic University of Korea YKYun Joong KimYonsei University DRDong-Woo RyuYeouido St. Mary's Hospital

Key Points

This research aims to investigate how the BDNF rs6265 polymorphism affects both motor and non-motor symptoms in individuals with Parkinson's disease.
Longitudinal study design examining BDNF rs6265 polymorphism
Assessment of motor progression and cognitive profiles
Focused on a Korean population
Identified variations in motor symptom progression linked to BDNF polymorphism
Differences in cognitive profiles associated with the BDNF variants
Suggests BDNF may play a role in modifying Parkinson's disease progression

Abstract

The differences in myocardial denervation at diagnosis, cognitive profiles, and motor progression might suggest a potential modulatory role of BDNF polymorphism in PD progression in the Korean population.

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Cite This Study

Yoo et al. (Tue,) studied this question.

synapsesocial.com/papers/6971be2c642b1836717e2c50 https://doi.org/https://doi.org/10.14802/jmd.25300

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